LIU Pharmacy and Health Sciences Core facilities offer researchers technology, tools and expertise to facilitate their research and become competitive for extramural grant funding. Core facilities collaborate across departments and divisions.
The Flow Cytometry Core provides access to the high-performance multicolor CytoFLEX Flow Cytometry System for single tube sample and plate loader accompanied by the CytExpert software for data analysis (Beckman Coulter, Life Sciences).
We provide flow cytometry training to members of the research community and students of the College of Pharmacy and Health Sciences. Investigators from other departments in Brooklyn campus are welcome to our facility. We are dedicated to providing the best training possible to ensure the best results attainable. The technology aids in cell counting, detecting biomarkers in complex subpopulations, identification and isolation of cancer stem cell, and functional assays.
Location: Wet Lab Building, Cancer Research Center, Room 206.
Contact: Eun-Jung Park, PhD,
LABORATORY ANIMAL FACILITY
Laboratory Animal Facility (LAF) operates as a research-support facility for the College of Pharmacy and Health Sciences and other Departments of Brooklyn campus. This facility offers housing, resources and management to provide animal-based research. Support functions include daily animal husbandry and supervision. Part-time veterinarian and veterinary technician provide assistance and training of students in addition to disease prevention, diagnosis and control. Regulatory control is by College of Pharmacy and Health Sciences Institutional Animal Care and Use Committee (IACUC).
Location: Wet Lab Building, Rooms 316,317
Contact: Grazia Stagni, PhD
Analytical Coreis equipped with advanced analytical instrumentation in support of pre-clinical drug development research, industrial drug development and compounding pharmacy activities. Capabilities for the Core are focused on physico-chemical and materials characterization including; solid state properties of APIs/excipients and dosage forms, chemical characteristics, chemical stability and degradant identification and quantitation, and the manifestation of processing and environmental stress throughout processing and storage. The instrumentation enables analysis in three broad categories: chemistry and solid state structural analyses (LC-MS, PXRD, Computational software); energetic analysis (DSC/TGA, sorption, UV, FTIR); and kinetic analysis (HPLC, dissolution, crystallizer), and micromeritics (Particle size, Microscopy).
Location: Wet Lab Building, Room 313B
Contact: Kenneth Morris, PhD
Manufacturing Core is equipped with tablet manufacturing capabilities from single station to 16 station tablet presses together with V-blender, roller compactor, fluid bed dryer (top and bottom), coating pan and recently acquired melt extruder. This core unit will cater to generic, brand, nutraceutical and cosmetic industry in helping them develop challenging products and serve them to solve for commonly associated problems with picking, sticking and other issues which they might face at their companies. It will also serve as a training hub for students, pharmaceutical scientists and governmental agencies employees.
Location: Wet Lab Building, Rooms
Contact: Rutesh Dave, PhD
STRUCTURE-BASED MOLECULAR AND COMPUTATIONAL DRUG DESIGN CORE
Structure-Based Molecular And Computational Drug Design Core is equipped with the Schrödinger Small Molecule Drug Discovery Suite used for in silico compound docking and analysis. Compounds can be evaluated de novo or using virtual libraries such as Zinc or Maybridge. The program suite includes built in capabilities for molecular dynamics simulations with Desmond, residue scanning, homology model building, site map prediction, free energy perturbation (FEP) calculations, and ADME filtering. In addition to computational drug design, open source program suites are available for macromolecular x-ray crystallography such as Phenix, CCP4, COOT, XDS, and iMosfilm.
Location: Health Sciences Building, Room 620
Contact: Kathleen Frey, PhD
SMALL ANIMAL IMAGING FACILITY
Small Animal Imaging Facility is a state of the art in vivo Imaging entity dedicated for a small animal research. Housing the Lumina LT system (Perkin Elmer), this lab will provide accurate anatomical and molecular bioluminescent and fluorescent imaging. The imaging modalities offer unprecedented opportunities to study in vivo small animal models of disease providing accurate assessment of disease initiation, progression and response to therapy. The lab will work with individual investigators to design experiments, imaging protocols (BL or F), and quantification techniques to meet individual needs.
The Animal Imaging Facility will operate with three aims:
- To provide access to in vivo imaging capabilities for College of Pharmacy and Health Sciences researchers, other Brooklyn campus researchers and collaborators
- To train new users and students in the theory of in vivo bioluminescence and fluorescence imaging and in the practice (operation) of our instrumentation
- To conduct novel research examining in vivo and ex vivo imaging techniques for disease mechanisms and progression, and drug bio-distribution studies
Location: Wet Lab Building, Cancer Research Center, Rooms 219
Contact: Avinash Kumar, Ph.D.